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29/12/2021

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HIV/AIDS Vaccine: Why Don’t We Have One After 37 Years, When We Have Several For COVID-19 After A Few Months?The Convers...
29/12/2021

HIV/AIDS Vaccine: Why Don’t We Have One After 37 Years, When We Have Several For COVID-19 After A Few Months?
The Conversation May 18, 2021

HIV/AIDS Vaccine: Why Don't We Have One After 37 Years, When We Have Several for COVID-19 After a Few Months? Giving Compass
Share Save 487 shares
Giving Compass' Take:
• Ronald C. Desrosiers explains why it is taking so long to develop an HIV/AIDS vaccine and points to promising breakthroughs that suggest that a solution is possible.

• What role can you play in advancing vaccine development and eventual distribution?

• Learn how to find and fund scientific research.

Smallpox has been eradicated from the face of the Earth following a highly effective, worldwide vaccination campaign. Paralytic poliomyelitis is no longer a problem in the U.S. because of development and use of effective vaccines against the poliovirus. In current times, millions of lives have been saved because of rapid deployment of effective vaccines against COVID-19. And yet, it has been 37 years since HIV was discovered as the cause of AIDS, and there is no vaccine. Here I will describe the difficulties facing development of an effective vaccine against HIV/AIDS.

I am a professor of pathology at the University of Miami Miller School of Medicine. My laboratory is credited with the discovery of the monkey virus called SIV, or simian immunodeficiency virus. SIV is the close monkey relative of the virus that causes AIDS in humans – HIV, or human immunodeficiency virus. My research has contributed importantly to the understanding of the mechanisms by which HIV causes disease and to vaccine development efforts.

Dr. Anthony Fauci discusses the difficulty of finding a vaccine for HIV/AIDS in 2017.
HIV vaccine development efforts have come up short
Vaccines have unquestionably been society’s most potent weapon against viral diseases of medical importance. When the new disease AIDS burst onto the scene in the early 1980s and the virus that caused it was discovered in 1983-84, it was only natural to think that the research community would be able to develop a vaccine for it.

At a now famous press conference in 1984 announcing HIV as the cause of AIDS, then U.S. Secretary of Health and Human Services Margaret Heckler predicted that a vaccine would be available in two years. Well, it is now 37 years later and there is no vaccine. The rapidity of COVID-19 vaccine development and distribution puts the lack of an HIV vaccine in stark contrast. The problem is not failure of government. The problem is not lack of spending. The difficulty lies in the HIV virus itself. In particular, this includes the remarkable HIV strain diversity and the immune evasion strategies of the virus.

So far there have been five large-scale Phase 3 vaccine efficacy trials against HIV, each at a cost of over US$100 million. The first three of these failed quite convincingly; no protection against acquisition of HIV infection, no lowering of viral loads in those who did become infected. In fact, in the third of these trials, the STEP trial, there was a statistically significant higher frequency of infection in individuals who had been vaccinated.

The fourth trial, the controversial Thai RV144 trial, initially reported a marginal degree of successful protection against the acquisition of HIV infection among vaccinated individuals. However, a subsequent statistical a**lysis reported that there was less than a 78% chance that the protection against acquisition was real.

A fifth vaccine trial, the HVTN 702 trial, was ordered to confirm and extend the results of the RV144 trial. The HVTN702 trial was halted early because of futility. No protection against acquisition. No lowering of viral load. Ouch.

The complexity of HIV
What is the problem? The biological properties that HIV has evolved make development of a successful vaccine very, very difficult. What are those properties?

First and foremost is the continuous unrelenting virus replication. Once HIV gets its foot in the door, it’s “gotcha.” Many vaccines do not protect absolutely against the acquisition of an infection, but they are able to severely limit the replication of the virus and any illness that might result. For a vaccine to be effective against HIV, it will likely need to provide an absolute sterilizing barrier and not just limit viral replication.

HIV has evolved an ability to generate and to tolerate many mutations in its genetic information. The consequence of this is an enormous amount of variation among strains of the virus not only from one individual to another but even within a single individual. Let’s use influenza for a comparison. Everyone knows that people need to get revaccinated against influenza virus each season because of season-to-season variability in the influenza strain that is circulating. Well, the variability of HIV within a single infected individual exceeds the entire worldwide sequence variability in the influenza virus during an entire season.

What are we going to put into a vaccine to cover this extent of strain variability?

HIV has also evolved an incredible ability to shield itself from recognition by antibodies. Enveloped viruses such as coronaviruses and herpes viruses encode a structure on their surface that each virus uses to gain entry into a cell. This structure is called a “glycoprotein,” meaning that it is composed of both sugars and protein. But the HIV envelope glycoprotein is extreme. It is the most heavily sugared protein of all viruses in all 22 families. More than half the weight is sugar. And the virus has figured out a way, meaning the virus has evolved by natural selection, to use these sugars as shields to protect itself from recognition by antibodies that the infected host is trying to make. The host cell adds these sugars and then views them as self.

These properties have important consequences relevant for vaccine development efforts. The antibodies that an HIV-infected person makes typically have only very weak neutralizing activity against the virus. Furthermore, these antibodies are very strain-specific; they will neutralize the strain with which the individual is infected but not the thousands and thousands of other strains circulating in the population. Researchers know how to elicit antibodies that will neutralize one strain, but not antibodies with an ability to protect against the thousands and thousands of strains circulating in the population. That’s a major problem for vaccine development efforts.

HIV is continually evolving within a single infected individual to stay one step ahead of the immune responses. The host elicits a particular immune response that attacks the virus. This puts selective pressure on the virus, and through natural selection a mutated virus variant appears that is no longer recognized by the individual’s immune system. The result is continuous unrelenting viral replication.

So, should we researchers give up? No, we shouldn’t. One approach researchers are trying in animal models in a couple of laboratories is to use herpes viruses as vectors to deliver the AIDS virus proteins. The herpes virus family is of the “persistent” category. Once infected with a herpes virus, you are infected for life. And immune responses persist not just as memory but in a continually active fashion. Success of this approach, however, will still depend on figuring out how to elicit the breadth of immune responses that will allow coverage against the vast complexity of HIV sequences circulating in the population.

Another approach is to go after protective immunity from a different angle. Although the vast majority of HIV-infected individuals make antibodies with weak, strain-specific neutralizing activity, some rare individuals do make antibodies with potent neutralizing activity against a broad range of HIV isolates. These antibodies are rare and highly unusual, but we scientists do have them in our possession.

Also, scientists have recently figured out a way to achieve protective levels of these antibodies for life from a single administration. For life! This delivery depends on a viral vector, a vector called adeno-associated virus. When the vector is administered to muscle, muscle cells become factories that continuously produce the potent broadly neutralizing antibodies. Researchers have recently documented continuous production for six and a half years in a monkey.
**VL: I think it’s this paper, quote from abstract “Here we report that monkey 84-05 has successfully maintained 240–350 μg/ml of anti-SIV antibody 5L7 for over 6 years”: https://dx.doi.org/10.3389%2Ffimmu.2020.00449)

We are making progress. We must not give up.

Long-term delivery of anti-HIV monoclonal antibodies using adeno-associated virus (AAV) holds promise for the prevention and treatment of HIV infection. We previously reported that after receiving a single administration of AAV vector coding for anti-SIV antibody 5L7, monkey 84-05 achieved high leve...

"Health is a state of complete harmony of the body, mind and spirit. Good health is not something we can buy..... Let's ...
22/08/2021

"Health is a state of complete harmony of the body, mind and spirit.
Good health is not something we can buy.....
Let's afford smile "mwanahawa needs us".
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For more direct details please call me on 0741829634.God bless.

20/07/2021

Kenya Red Cross Society Ministry of Health and Sports, Kenya.
There are many things that you can do to help a friend or loved one who has been recently diagnosed with HIV:
Talk. Be available to have open, honest conversations about HIV. ...
Listen. Being diagnosed with HIV is life-changing news. ...
Learn. ...
Encourage treatment. ...
Support medication adherence. ...
Get support.
Health is wealth have started this program across to assist and encourage the young people living with HIV/AIDS.
World Health Organization (WHO) USAID - US Agency for International Development
Working towards supporting the youth.Health being the number one top priority.
THE NATURE OF THE HIV/AIDS EPIDEMICS
AMONG INJECTING DRUG USERS
HIV/AIDS epidemics among IDUs tend to manifest themselves very differently
from epidemics in which s*xual transmission is the main risk factor. Although
s*xually transmitted HIV may remain virtually invisible for several years until the
burden of disease slowly increases, sharing of injection equipment is a much
more efficient mode of transmission, and drug-related epidemics therefore
spread more rapidly. Once the virus is introduced into a community of IDUs, tens
of thousands of HIV infections may occur. Infection levels among IDUs may rise
from zero to 50–60% within 1–2 years, as demonstrated in cities as different
as St Petersburg (Russian Federation), Imphal (Manipur, India) or Ruili (Yunnan
Province, China).
The size of the drug-related HIV/AIDS epidemics that result largely depends on
the number of people in a given location that regularly or occasionally inject
(illicit) drugs and their risk behaviour. The size of the drug-injecting problem
in turn usually depends on several factors, including the supplies of injectable
drugs, such as he**in, amphetamines and co***ne; drug demand; and the
patterns and norms of use among young people, such as whether drugs tend
to be injected versus smoked or inhaled. Drug-related HIV/AIDS epidemics
have followed the spread of co***ne injecting in Latin America and of he**in
injecting in Asia in the 1980s and the massive spread of the injecting of he**in
and other opiates in eastern Europe in the 1990s.
Injecting drug use has now been documented in 129 countries, 79 of which
also report HIV transmission through contaminated needles, syringes and other
injecting equipment. About 13 million people worldwide inject drugs, and about
10% of all new HIV infections globally result from the use of contaminated
injecting equipment by IDUs. In many countries in Europe, Asia, the Middle
East and the Southern Cone of Latin America, the use of non-sterile injecting
equipment by IDUs has remained the most important mode of HIV transmission,
accounting for between 30% and 80% of all reported infections (Fig. 1). The
potential for HIV to spread from IDUs to their non-injecting s*xual partners
and the wider population differs from country to country and depends on the
s*xual behaviour of IDUs, their partners and the community at large and on
s*xual mixing patterns.
As the number of HIV-infected IDUs grows in many developing and transitional
countries, not only programmes for HIV/AIDS prevention and drug dependence
treatment but also AIDS care and support services are facing new and increasing
challenges. In many countries and regions, the twin epidemics of injecting drug
use and HIV infection linked to sharing of injection equipment have already
profoundly affected health, and social and economic well-being.
INTRODUCTION
4 ADVOCACY GUIDE: HIV/AIDS PREVENTION AMONG INJECTING DRUG USERS
Figure 1. Regions in which needle and syringe sharing is the major mode of HIV
transmission
Although injecting drug use is predominantly a city phenomenon, it is increasing
in non-urban or semi-urban areas, along drug trafficking routes, in economically
depressed communities and among marginalized ethnic minorities. The age at
which people begin to inject drugs varies considerably and depends on factors
such as social cohesion, norms and drug availability. In the Commonwealth of
Independent States, injecting is especially frequent among young people, with
initiation starting as early as 12 years of age. Between 65% and 90% of IDUs
in developing and transitional countries are men 15–35 years old. However,
the proportion of IDUs who are women and girls is reported to be increasing
in some countries. Although all IDUs using potentially contaminated injecting
equipment are at high risk of HIV infection, specific populations are especially
susceptible to infection. These include young IDUs, because of inexperience
in obtaining clean injecting equipment; female IDUs, because of s*xual risk
and injecting practices over which they may have less control and because
of exclusion from services; and the increasing number of drug-injecting s*x
workers, both male and female. Similarly, inmates of prisons and other
correctional institutions are at an increased risk of HIV infection because they
lack access to preventive services.
All these particularities of HIV/AIDS epidemics among IDUs, including their
linkage to illicit drug use patterns, their potentially explosive spread within
communities of IDUs, the risk of further spread via s*xual in*******se to the
wider community and the specific vulnerability and risks of particular groups of
IDUs need to be considered when advocating for services and programmes.
Latin America
Southern Cone
IDU is Major Mode of Transmission, 30-90 % of infections
North America
East Asia
Southern Europe
North Africa &
Middle East
Eastern Europe & Central Asia
5
COMPREHENSIVE HIV/AIDS PREVENTION
AMONG INJECTING DRUG USERS
Explosive epidemics have been occurring among IDUs in many different
locations, but evidence shows that HIV/AIDS epidemics among IDUs can be
prevented, slowed, stopped and even reversed.1 In principle, the risk of HIV
spread through the sharing of infected injection equipment can be reduced if:
fewer people use drugs and especially those that are injected;
those continuing to inject drugs do so less frequently and more
safely: without sharing injection equipment.
Numerous programme and service options aim to facilitate a continuum of
behavioural changes among IDUs. Young people at risk of using drugs are
assisted in avoiding drug use in the first place and in initiating drug injecting in
particular. Those experimenting with injecting drugs are encouraged to stop,
to revert to other means of consumption such as smoking and ingesting or
at least to inject less frequently. Those regularly injecting and dependent on
drugs are offered drug dependence treatment including, where appropriate,
substitution with oral drugs such as methadone. Those not willing to enter
or not having access to drug dependence treatment and not in contact with
health institutions are offered services through outreach and are provided risk
reduction information and clean injection equipment, as well as condoms, and
referral to treatment, as available.
Experience has shown that halting the epidemic requires: (i) preventing drug
abuse, (ii) facilitating entry into drug treatment and (iii) establishing effective
outreach to engage IDUs in HIV/AIDS prevention strategies that protect them
and their partners and families from exposure to HIV and encourage the uptake
of drug dependence treatment and health care. This three-part strategy is
often referred to as the comprehensive package of interventions for HIV/AIDS
prevention among IDUs. It may include, as individual service elements, drug
abuse prevention, AIDS education, life skills training, condom distribution,
voluntary and confidential counselling and HIV testing, access to clean needles
and syringes, bleach materials and referral to a variety of treatment options.2
INTRODUCTION
1 For example, all Australian cities, London (United Kingdom) and Dhaka (Bangladesh) have maintained HIV prevalence
among IDUs at less than 5%; the epidemic among IDUs in Nepal appears to have been delayed for several years; and HIV
prevalence among IDUs in New York City, Edinburgh and Brazilian cities has fallen.
2 Preventing the transmission of HIV among drug abusers: a position paper of the United Nations System. Annex to the Report
of the 8th Session of the Administrative Committee on Coordination Subcommittee on Drug Control, 28–29 September
2000. Geneva, United Nations, 2000 (http://www.unaids.org/publications/documents/specifi c/injecting/Hraids.doc).
6 ADVOCACY GUIDE: HIV/AIDS PREVENTION AMONG INJECTING DRUG USERS
Unfortunately, certain effective but controversial elements are neglected in
many countries. This imbalance must be redressed to reach many people at the
highest risk and halt HIV epidemics. Important service elements that tend to be
neglected include drug dependence treatment, outreach activities and needle
and syringe programmes.
Drug dependence treatment, especially drug substitution treatment such as
methadone maintenance, therapeutic communities and outpatient drug-free
programmes, assists IDUs in significantly reducing their drug consumption and
the frequency of injecting or in ceasing illicit drug use altogether. Voluntary
treatment tends to be much more successful than mandatory treatment. Drug
dependence treatment facilities in many developing and transitional countries
have low capacity and sometimes low quality and lack serious funding support.
Outreach activities motivate and support IDUs who are not in treatment to
reduce their risk behaviour, both sharing of injection equipment and s*xual
transmission. Research indicates that outreach activities taking place outside the
conventional health and social care environments can reach out-of-treatment
IDUs and increase the rate of drug treatment referrals. In many countries,
outreach to IDUs is not part of recognized service packages.
Needle and syringe programmes are usually part of outreach activities and
reduce the risk of HIV transmission through the sharing of drug use paraphernalia
among those not in treatment. They serve as points of contact between IDUs and
service providers, including from drug treatment programmes. The benefits of
such programmes are considerable and increase further if they go beyond needle
and syringe distribution to include AIDS education, counselling and referral to
a variety of treatment options. Nevertheless, resistance to needle and syringe
programmes remains considerable. They are sometimes believed to incite noninjectors to use drugs even though there is no evidence that such programmes
increase the rate of injecting drug use or other public health dangers in the
communities where they are implemented.
Further, HIV/AIDS prevention usually needs to be strengthened within the
criminal justice system. HIV/AIDS prevention in penal institutions may include
two distinct strategies, both of which tend to be lacking, even in severely
affected countries.
Firstly, where there is increased risks of HIV transmission in penal institutions,
the number of drug-dependent IDUs incarcerated should be reduced if possible.
There may, for instance, be scope to replace mandatory prison sentences for those
possessing small amounts of drugs by alternatives, including community service,
and offers of drug dependence treatment.
Secondly, HIV prevention and drug treatment programmes within penal institutions
are important components of a comprehensive response to prevent the transmission
of HIV, as injecting and dependence tend to continue in detention.
7
Both strategies are too rarely implemented. Programmes to prevent HIV/AIDS in
prisons are often hampered by governments denying the existence of injecting
drug use and s*xual in*******se in institutions of criminal justice. In reality, drug
use in general and injecting drug use in particular (as well as s*xual in*******se
between men) are frequent in such institutions in many, if not most, countries.
Available data indicate that the rates of HIV infection among inmates are
significantly higher than in the general population in some countries, reflecting
at least in part continued exposure to HIV among inmates.
In addition, the trafficking, injecting (and consumption in general) of substances
such as he**in, other opiates, co***ne and amphetamines are illegal in most
countries worldwide. HIV/AIDS prevention and drug control policies often need
to be harmonized further, for example, to avoid that punishment renders IDUs
more vulnerable to HIV. A balance must be struck between public health and
public order.
Another programme area that is often neglected is the lack of appropriate HIV
prevention services for young IDUs. Most services concentrate on adults or those
who have already injected for some time and are addicted and perhaps already
infected. Especially in some regions, such as eastern Europe, many young people
experiment with drugs, using drugs on weekends, irregularly and recreationally
– making standard interventions that only target marginalized addicted drug
users, the stereotypical “junkie in the street”, inappropriate. Similarly, female
IDUs are frequently underserved.
In conclusion, drawing on policies expressed in the United Nations drug control
conventions and the Declaration on the Guiding Principles of Drug Demand
Reduction, United Nations human rights documents and United Nations
documents on health promotion policy, the following principles and strategic
approaches should be used for addressing HIV/AIDS among IDUs.
Protecting human rights is critical to success in preventing HIV/AIDS.
People are more vulnerable to infection when their economic, health,
social or cultural rights are not respected. Responding effectively to the
epidemic is difficult if civil rights are not respected.
HIV prevention should start as early as possible. Once HIV has been
introduced into a local community of IDUs, it may spread extremely
rapidly.
Interventions should be based on regular assessment of the nature and
magnitude of drug use as well as trends and patterns of HIV infection.
Comprehensive coverage of the entire population is essential. As many
individuals in the at-risk populations as possible must be reached for
prevention measures to be effective in changing the course of the
epidemic in a country.
INTRODUCTION
8 ADVOCACY GUIDE: HIV/AIDS PREVENTION AMONG INJECTING DRUG USERS
The reduction of drug demand and HIV prevention programmes should
be integrated into broader social welfare and health promotion policies
and preventive education programmes. A supportive environment
in which healthy lifestyles are attractive and achievable, including
poverty reduction and opportunities for education and employment,
should sustain specific interventions for reducing demand for drugs and
preventing HIV transmission.
Drug problems cannot be solved by criminal justice initiatives alone. A
punitive approach may drive the people who most need prevention and
care services underground.
Treatment services need to be readily available and flexible. Treatment
systems need to offer a range of treatment alternatives, including substitution
treatment, to respond to the different needs of groups of IDUs.
Developing effective responses to the problem of HIV among IDUs is
facilitated by assuring the active participation of the target group in all
phases of developing and implementing the programme.
Drug treatment programmes should provide assessment for HIV/AIDS
and other infectious diseases and counselling to help IDUs change
behaviour that places them or others at risk of infection.
HIV/AIDS prevention programmes should also focus on s*xual risk
behaviour among people who inject drugs or use other substances.
Outreach work and peer education outside normal service settings, and
normal working hours are needed to extend services to groups that are
not effectively reached by existing traditional health services. Specific
services may be needed for young IDUs, women and s*x workers.
Adequate resources are required to respond to the increase in client
load that is likely to result from outreach work.
Care and support, involving community participation, must be provided
to IDUs living with HIV/AIDS and to their families, including access to
affordable clinical and home-based care, effective HIV prevention
interventions, essential legal and social services, psychosocial support
and counselling services.

I need support reach out to this young,energetic,talented young men and oustanding women outside here/.

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20/07/2021

What can I do if I think I was exposed to HIV?
Kenya state Department of Health’s HIV Clinical Guidelines recommend
non-occupational post exposure prophylaxis (nPEP or PEP) at certain times
when a person is potentially exposed to HIV, for example when a condom
breaks, during a s*xual assault, with sharing needles or works, or during
other exposures to blood or other potentially infected body fluids. PEP
involves taking a combination of HIV medicines for 28 days. PEP should be
started as soon as possible, ideally within 2 hours of exposure. Decisions
regarding initiation of PEP beyond 36 hours but no longer than 72 hours
after the exposure are made on a case by case basis, keeping in mind that
the medicine is most effective the closer it can be taken to the exposure.
The DOH has a fact sheet that a person who has been exposed to HIV
can take to the emergency room to explain his or her special need.
You can find that fact sheet at:

For PEP to work, every dose of each medicine prescribed must be taken,
for the full period of time. PEP can be expensive and insurance coverage
may vary, but options for payment assistance can be found on the

Payment is available for s*xual assault victims. Talk to your healthcare
provider or an emergency room doctor right away if you think you’ve
recently been exposed to HIV.

20/07/2021

There is no vaccine to prevent HIV but there are several ways a person
can feel confident about avoiding HIV through s*xual behavior. Practicing
abstinence, that is, not having va**nal or a**l in*******se, is one way
to protect yourself from HIV. Cuddling, hugging, kissing or mutual
ma********on have no risk of passing HIV from one partner to the other.
Mutual monogamy, where both partners have been tested and know
they are both HIV negative and are not having s*x with anyone else, also
provides protection.
Here are other choices that some people make to avoid HIV. These
approaches offer a very high level of protection:
• If you have a partner who is living with HIV, if he or she is on
effective treatment and maintains an undetectable viral load (i.e. the
person is virally suppressed), for 6 months and beyond the risk of
transmission through s*x is negligible.
• Using a condom consistently and correctly every time you have s*x
is extremely effective in preventing HIV.
• Pre-Exposure Prophylaxis (PrEP): PrEP is a once-a-day pill for HIV
negative individuals to take in order to prevent HIV. When taken
consistently, PrEP has been shown to reduce the risk of HIV by
92-99%.
• Giving and receiving oral s*x is considered a low-risk activity for
HIV transmission.
If a person has va**nal or a**l in*******se without condoms or PrEP,
there are important ways to reduce the risk of HIV transmission. These
are considered harm reduction strategies, because there is still a risk of
getting HIV if a partner is living with the virus and is not virally suppressed.
10
Use of lubrication: Extra lubrication, like KY jelly, can reduce the chance
of cuts and tears in the skin or mucus membranes of the p***s, re**um or
va**na. This reduces the chance of blood being present and reduces the
ability of HIV to enter the body.
• Strategic Positioning: During a**l s*x, there is a penetrative partner
(“top”) and a receptive partner (“bottom”). Being the penetrative
partner is less of a risk for acquiring HIV than being a receptive partner.
However, there is still an element of risk involved in both positions.
• Frequent STD screening and treatment: A sore or inflammation
from an STD may allow HIV to enter the body of a person who does
not have HIV, when it typically would have been stopped by intact
skin. For people living with HIV, having an STD/STI can increase the
chance of passing the virus to others.

U=U means undetectable = untransmittable. U=U was put forth bythe Prevention Access Campaign (https://www.preventionacce...
20/07/2021

U=U means undetectable = untransmittable. U=U was put forth by
the Prevention Access Campaign (https://www.preventionaccess.org/
undetectable). The Prevention Access Campaign is a health equity
initiative to end the dual epidemics of HIV and HIV-related stigma by
empowering people living with, and vulnerable to HIV, with accurate and
meaningful information about their social, s*xual, and reproductive health.
In developing U=U, the Prevention Access Campaign reviewed data from
several large-scale studies and compiled the findings into a statement
which many leading scientists and public health organizations have
endorsed.
9
The U=U Consensus Statement is:
People with HIV on ART with an undetectable viral load in their blood
have a negligible risk of s*xual transmission of HIV. Depending on the
drugs employed it may take as long as six months for the viral load to
become undetectable. Continued and reliable HIV suppression requires
selection of appropriate agents and excellent adherence to treatment. HIV
viral suppression should be monitored to assure both personal health and
public health benefits.
When making decisions about HIV prevention, individuals and couples should
explore their level of comfort with the full range of prevention options and
make decisions regarding use of U=U, condoms or PrEP accordingly.

A customizable social marketing campaign that you can use to educate about U=U and encourage engagement in care. See what POZ Magazine has to say about +series.

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